RapamycinFungusV1, Main, Exploration, bibRecord, 000463

The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection.

Identifieur interne : 000463 ( Main/Exploration ); précédent : 000462; suivant : 000464

The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection.

Source :

Frontiers in immunology [ 1664-3224 ] ; 2018.

RBID : pubmed:29875775

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Biomarkers (MeSH), CD3 Complex (metabolism), Cell Differentiation (immunology), Cell Lineage (MeSH), Cell Movement (immunology), Computational Biology (methods), Disease Models, Animal (MeSH), Gene Expression Profiling (MeSH), Humans (MeSH), Immunity, Humoral (MeSH), Inducible T-Cell Co-Stimulator Protein (metabolism), Mechanistic Target of Rapamycin Complex 2 (metabolism), Mice (MeSH), Mice, Transgenic (MeSH), Signal Transduction (MeSH), T-Lymphocytes, Helper-Inducer (immunology), T-Lymphocytes, Helper-Inducer (metabolism), Virus Diseases (immunology), Virus Diseases (metabolism), Virus Diseases (virology).
MESH :
- chemical , metabolism : CD3 Complex, Inducible T-Cell Co-Stimulator Protein, Mechanistic Target of Rapamycin Complex 2.
- chemical : Biomarkers.
- immunology : Cell Differentiation, Cell Movement, T-Lymphocytes, Helper-Inducer, Virus Diseases.
- metabolism : T-Lymphocytes, Helper-Inducer, Virus Diseases.
- methods : Computational Biology.
- virology : Virus Diseases.
- Animals, Cell Lineage, Disease Models, Animal, Gene Expression Profiling, Humans, Immunity, Humoral, Mice, Mice, Transgenic, Signal Transduction.

Abstract

Follicular helper CD4⁺ T (T_FH) cells are critical for optimal B-cell-mediated humoral immunity by initiating, fueling, and sustaining germinal center reactions. The differentiation of T_FH cells relies on multiple intrinsic and extrinsic factors; however, the details by which these factors are integrated to coordinate T_FH differentiation are largely unknown. In this study, using a mouse model of acute lymphocytic choriomeningitis virus (LCMV) viral infection, we demonstrate that mTOR complex 2 (mTORC2) kinase integrates TCR signaling and ICOS-mediated co-stimulation to promote late differentiation and functional maturation of virus-specific T_FH cells. Specifically, mTORC2 functions to maintain T_FH lineage specifications, including phenotypes, migratory characteristics, and functional properties. Thus, our results highlight the importance of mTORC2 in guarding T_FH phenotypic and functional maturation.

DOI: 10.3389/fimmu.2018.01127
PubMed: 29875775
PubMed Central: PMC5974104

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000535
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Le document en format XML

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<author><name sortKey="Tian, Qin" sort="Tian, Qin" uniqKey="Tian Q" first="Qin" last="Tian">Qin Tian</name>
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<author><name sortKey="Bai, Qiang" sort="Bai, Qiang" uniqKey="Bai Q" first="Qiang" last="Bai">Qiang Bai</name>
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<author><name sortKey="Chen, Xiangyu" sort="Chen, Xiangyu" uniqKey="Chen X" first="Xiangyu" last="Chen">Xiangyu Chen</name>
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<author><name sortKey="Li, Zhirong" sort="Li, Zhirong" uniqKey="Li Z" first="Zhirong" last="Li">Zhirong Li</name>
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<author><name sortKey="Xie, Zhunyi" sort="Xie, Zhunyi" uniqKey="Xie Z" first="Zhunyi" last="Xie">Zhunyi Xie</name>
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<author><name sortKey="Zhou, Xinyuan" sort="Zhou, Xinyuan" uniqKey="Zhou X" first="Xinyuan" last="Zhou">Xinyuan Zhou</name>
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<author><name sortKey="Zhou, Yuyang" sort="Zhou, Yuyang" uniqKey="Zhou Y" first="Yuyang" last="Zhou">Yuyang Zhou</name>
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<author><name sortKey="Yin, Zhinan" sort="Yin, Zhinan" uniqKey="Yin Z" first="Zhinan" last="Yin">Zhinan Yin</name>
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<region type="province">Guangdong</region>
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<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu</wicri:regionArea>
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<author><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Ye, Lilin" sort="Ye, Lilin" uniqKey="Ye L" first="Lilin" last="Ye">Lilin Ye</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4<sup>+</sup>
 T Cells During Viral Infection.</title>
<author><name sortKey="Hao, Yaxing" sort="Hao, Yaxing" uniqKey="Hao Y" first="Yaxing" last="Hao">Yaxing Hao</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yifei" sort="Wang, Yifei" uniqKey="Wang Y" first="Yifei" last="Wang">Yifei Wang</name>
<affiliation wicri:level="3"><nlm:affiliation>The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Xiaobing" sort="Liu, Xiaobing" uniqKey="Liu X" first="Xiaobing" last="Liu">Xiaobing Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Xia" sort="Yang, Xia" uniqKey="Yang X" first="Xia" last="Yang">Xia Yang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
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<author><name sortKey="Wang, Pengcheng" sort="Wang, Pengcheng" uniqKey="Wang P" first="Pengcheng" last="Wang">Pengcheng Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tian, Qin" sort="Tian, Qin" uniqKey="Tian Q" first="Qin" last="Tian">Qin Tian</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bai, Qiang" sort="Bai, Qiang" uniqKey="Bai Q" first="Qiang" last="Bai">Qiang Bai</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xiangyu" sort="Chen, Xiangyu" uniqKey="Chen X" first="Xiangyu" last="Chen">Xiangyu Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Zhirong" sort="Li, Zhirong" uniqKey="Li Z" first="Zhirong" last="Li">Zhirong Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Jialin" sort="Wu, Jialin" uniqKey="Wu J" first="Jialin" last="Wu">Jialin Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xie, Zhunyi" sort="Xie, Zhunyi" uniqKey="Xie Z" first="Zhunyi" last="Xie">Zhunyi Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Xinyuan" sort="Zhou, Xinyuan" uniqKey="Zhou X" first="Xinyuan" last="Zhou">Xinyuan Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Yuyang" sort="Zhou, Yuyang" uniqKey="Zhou Y" first="Yuyang" last="Zhou">Yuyang Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yin, Zhinan" sort="Yin, Zhinan" uniqKey="Yin Z" first="Zhinan" last="Yin">Zhinan Yin</name>
<affiliation wicri:level="3"><nlm:affiliation>The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Lilin" sort="Ye, Lilin" uniqKey="Ye L" first="Lilin" last="Ye">Lilin Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Immunology, Third Military Medical University, Chongqing</wicri:regionArea>
<wicri:noRegion>Chongqing</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in immunology</title>
<idno type="ISSN">1664-3224</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Biomarkers (MeSH)</term>
<term>CD3 Complex (metabolism)</term>
<term>Cell Differentiation (immunology)</term>
<term>Cell Lineage (MeSH)</term>
<term>Cell Movement (immunology)</term>
<term>Computational Biology (methods)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunity, Humoral (MeSH)</term>
<term>Inducible T-Cell Co-Stimulator Protein (metabolism)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (metabolism)</term>
<term>Mice (MeSH)</term>
<term>Mice, Transgenic (MeSH)</term>
<term>Signal Transduction (MeSH)</term>
<term>T-Lymphocytes, Helper-Inducer (immunology)</term>
<term>T-Lymphocytes, Helper-Inducer (metabolism)</term>
<term>Virus Diseases (immunology)</term>
<term>Virus Diseases (metabolism)</term>
<term>Virus Diseases (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Antigènes CD3 (métabolisme)</term>
<term>Biologie informatique (méthodes)</term>
<term>Complexe-2 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Différenciation cellulaire (immunologie)</term>
<term>Humains (MeSH)</term>
<term>Immunité humorale (MeSH)</term>
<term>Lignage cellulaire (MeSH)</term>
<term>Lymphocytes T auxiliaires (immunologie)</term>
<term>Lymphocytes T auxiliaires (métabolisme)</term>
<term>Maladies virales (immunologie)</term>
<term>Maladies virales (métabolisme)</term>
<term>Maladies virales (virologie)</term>
<term>Marqueurs biologiques (MeSH)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Mouvement cellulaire (immunologie)</term>
<term>Protéine inductible de costimulation du lymphocyte T (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Souris transgéniques (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>CD3 Complex</term>
<term>Inducible T-Cell Co-Stimulator Protein</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Différenciation cellulaire</term>
<term>Lymphocytes T auxiliaires</term>
<term>Maladies virales</term>
<term>Mouvement cellulaire</term>
</keywords>
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<term>Cell Movement</term>
<term>T-Lymphocytes, Helper-Inducer</term>
<term>Virus Diseases</term>
</keywords>
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<term>Virus Diseases</term>
</keywords>
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</keywords>
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<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Lymphocytes T auxiliaires</term>
<term>Maladies virales</term>
<term>Protéine inductible de costimulation du lymphocyte T</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Biologie informatique</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Virus Diseases</term>
</keywords>
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<term>Cell Lineage</term>
<term>Disease Models, Animal</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Immunity, Humoral</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Signal Transduction</term>
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<term>Animaux</term>
<term>Humains</term>
<term>Immunité humorale</term>
<term>Lignage cellulaire</term>
<term>Marqueurs biologiques</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris</term>
<term>Souris transgéniques</term>
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<front><div type="abstract" xml:lang="en">Follicular helper CD4<sup>+</sup>
 T (T<sub>FH</sub>
) cells are critical for optimal B-cell-mediated humoral immunity by initiating, fueling, and sustaining germinal center reactions. The differentiation of T<sub>FH</sub>
 cells relies on multiple intrinsic and extrinsic factors; however, the details by which these factors are integrated to coordinate T<sub>FH</sub>
 differentiation are largely unknown. In this study, using a mouse model of acute lymphocytic choriomeningitis virus (LCMV) viral infection, we demonstrate that mTOR complex 2 (mTORC2) kinase integrates TCR signaling and ICOS-mediated co-stimulation to promote late differentiation and functional maturation of virus-specific T<sub>FH</sub>
 cells. Specifically, mTORC2 functions to maintain T<sub>FH</sub>
 lineage specifications, including phenotypes, migratory characteristics, and functional properties. Thus, our results highlight the importance of mTORC2 in guarding T<sub>FH</sub>
 phenotypic and functional maturation.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29875775</PMID>
<DateCompleted><Year>2019</Year>
<Month>07</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>07</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-3224</ISSN>
<JournalIssue CitedMedium="Print"><Volume>9</Volume>
<PubDate><Year>2018</Year>
</PubDate>
</JournalIssue>
<Title>Frontiers in immunology</Title>
<ISOAbbreviation>Front Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4<sup>+</sup>
 T Cells During Viral Infection.</ArticleTitle>
<Pagination><MedlinePgn>1127</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3389/fimmu.2018.01127</ELocationID>
<Abstract><AbstractText>Follicular helper CD4<sup>+</sup>
 T (T<sub>FH</sub>
) cells are critical for optimal B-cell-mediated humoral immunity by initiating, fueling, and sustaining germinal center reactions. The differentiation of T<sub>FH</sub>
 cells relies on multiple intrinsic and extrinsic factors; however, the details by which these factors are integrated to coordinate T<sub>FH</sub>
 differentiation are largely unknown. In this study, using a mouse model of acute lymphocytic choriomeningitis virus (LCMV) viral infection, we demonstrate that mTOR complex 2 (mTORC2) kinase integrates TCR signaling and ICOS-mediated co-stimulation to promote late differentiation and functional maturation of virus-specific T<sub>FH</sub>
 cells. Specifically, mTORC2 functions to maintain T<sub>FH</sub>
 lineage specifications, including phenotypes, migratory characteristics, and functional properties. Thus, our results highlight the importance of mTORC2 in guarding T<sub>FH</sub>
 phenotypic and functional maturation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hao</LastName>
<ForeName>Yaxing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yifei</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xiaobing</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Xia</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Pengcheng</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Qin</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bai</LastName>
<ForeName>Qiang</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Xiangyu</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Zhirong</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Jialin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Zhunyi</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Xinyuan</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Yuyang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yin</LastName>
<ForeName>Zhinan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Yuzhang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Lilin</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute of Immunology, Third Military Medical University, Chongqing, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>05</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Front Immunol</MedlineTA>
<NlmUniqueID>101560960</NlmUniqueID>
<ISSNLinking>1664-3224</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017252">CD3 Complex</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D060889">Inducible T-Cell Co-Stimulator Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076225">Mechanistic Target of Rapamycin Complex 2</NameOfSubstance>
</Chemical>
</ChemicalList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017252" MajorTopicYN="N">CD3 Complex</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019070" MajorTopicYN="N">Cell Lineage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056724" MajorTopicYN="N">Immunity, Humoral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060889" MajorTopicYN="N">Inducible T-Cell Co-Stimulator Protein</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076225" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 2</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006377" MajorTopicYN="N">T-Lymphocytes, Helper-Inducer</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">B cells</Keyword>
<Keyword MajorTopicYN="Y">acute viral infection</Keyword>
<Keyword MajorTopicYN="Y">follicular helper T cells</Keyword>
<Keyword MajorTopicYN="Y">germinal center</Keyword>
<Keyword MajorTopicYN="Y">mechanistic target of rapamycin complex 2</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>03</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>05</Month>
<Day>04</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>6</Month>
<Day>8</Day>
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<ReferenceList><Reference><Citation>Elife. 2016 Sep 30;5:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27690224</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2013 Apr 18;38(4):805-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23583644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2017 Sep 19;47(3):538-551.e5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28930662</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16199517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2011 Jun 24;34(6):932-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21636296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2007 Aug;27(2):190-202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17723214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2008 Jul 18;29(1):138-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18599325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2004 Aug 15;18(16):1926-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15314020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2010 Feb 15;207 (2):365-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20142430</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2012 Apr 20;12(5):325-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22517423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 2012;30:429-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22224772</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2013 Apr 25;496(7446):523-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23619696</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7797-802</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18509048</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19812304</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011 Mar 14;6(3):e17739</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21423809</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2014 Apr 15;192(8):3607-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24646739</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2014 Oct 16;41(4):529-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25367570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immune Netw. 2016 Aug;16(4):219-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27574501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2013 Apr 1;190(7):3049-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23447690</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1993 Nov 1;151(9):4505-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7691953</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2009 May;10(5):307-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19339977</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 May 1;188(9):4217-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22450810</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2003 Aug;194:8-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12846803</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2011 Mar 4;144(5):757-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21376236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Immunol. 2016 Dec;43:24-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27588918</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2005 Jun 15;105(12):4743-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15746082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2013 Apr 15;190(8):4014-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23487426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Immunol. 1998 Jan;28(1):390-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9485218</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2007 Oct 15;179(8):5099-108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17911595</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2004 Nov;6(11):1122-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15467718</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2010 Jun 25;32(6):743-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20620941</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2012 May 20;14 (7):686-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22609986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Aug 21;325(5943):1006-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19608860</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21157483</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2011 Jun 24;34(6):947-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21636295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2010 Jul 30;39(2):171-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20670887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Semin Immunol. 1996 Jun;8(3):179-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8738917</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2009 Jul;10(7):769-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19483717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2008 Mar 17;205(3):565-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18283119</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Elife. 2014 Oct 27;3:null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25347065</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1995 Jul 15;155(2):556-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7541819</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2011 May 1;186(9):5294-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21441451</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Aug 21;325(5943):1001-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19628815</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2015 Sep;16(9):980-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26214741</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3987-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7732018</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2002 Jan 1;30(1):207-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11752295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2015 Oct 20;43(4):690-702</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26410627</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2013 Apr 15;201(2):293-308</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23569215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2011 Jul 15;10(14):2305-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21670596</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2012 Apr 13;149(2):274-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22500797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 Jun 19;30(6):832-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19538929</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO Rep. 2014 Feb;15(2):191-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24375676</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2011 Apr;12(4):295-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21358638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2001 Jun 18;193(12):1373-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11413192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Rep. 2015 Sep 29;12(12):2099-110</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26365183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1999 Oct 18;190(8):1123-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10523610</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2014 Mar 27;507(7493):513-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24463518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2016 Sep 20;45(3):540-554</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27637146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2000 Aug;176:181-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11043777</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 Sep 18;31(3):457-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19631565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2015 Sep;16(9):991-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26214740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Oct 9;455(7214):764-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18843362</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2004 Jul 27;14(14):1296-302</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15268862</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2000 Dec 4;192(11):1545-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11104797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2005 Jun;3(6):e150</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15857154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2013 Jul;87(13):7737-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23637417</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2011 Aug 1;187(3):1091-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21715693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 2018;1707:15-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29388097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 2011;29:621-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21314428</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1998 Jul 3;281(5373):96-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9651253</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2010 Feb 15;207 (2):353-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20142429</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2000 Dec 4;192(11):1553-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11104798</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<region><li>Guangdong</li>
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<name sortKey="Bai, Qiang" sort="Bai, Qiang" uniqKey="Bai Q" first="Qiang" last="Bai">Qiang Bai</name>
<name sortKey="Chen, Xiangyu" sort="Chen, Xiangyu" uniqKey="Chen X" first="Xiangyu" last="Chen">Xiangyu Chen</name>
<name sortKey="Li, Zhirong" sort="Li, Zhirong" uniqKey="Li Z" first="Zhirong" last="Li">Zhirong Li</name>
<name sortKey="Liu, Xiaobing" sort="Liu, Xiaobing" uniqKey="Liu X" first="Xiaobing" last="Liu">Xiaobing Liu</name>
<name sortKey="Tian, Qin" sort="Tian, Qin" uniqKey="Tian Q" first="Qin" last="Tian">Qin Tian</name>
<name sortKey="Wang, Pengcheng" sort="Wang, Pengcheng" uniqKey="Wang P" first="Pengcheng" last="Wang">Pengcheng Wang</name>
<name sortKey="Wang, Yifei" sort="Wang, Yifei" uniqKey="Wang Y" first="Yifei" last="Wang">Yifei Wang</name>
<name sortKey="Wu, Jialin" sort="Wu, Jialin" uniqKey="Wu J" first="Jialin" last="Wu">Jialin Wu</name>
<name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name>
<name sortKey="Xie, Zhunyi" sort="Xie, Zhunyi" uniqKey="Xie Z" first="Zhunyi" last="Xie">Zhunyi Xie</name>
<name sortKey="Yang, Xia" sort="Yang, Xia" uniqKey="Yang X" first="Xia" last="Yang">Xia Yang</name>
<name sortKey="Ye, Lilin" sort="Ye, Lilin" uniqKey="Ye L" first="Lilin" last="Ye">Lilin Ye</name>
<name sortKey="Yin, Zhinan" sort="Yin, Zhinan" uniqKey="Yin Z" first="Zhinan" last="Yin">Zhinan Yin</name>
<name sortKey="Yin, Zhinan" sort="Yin, Zhinan" uniqKey="Yin Z" first="Zhinan" last="Yin">Zhinan Yin</name>
<name sortKey="Zhou, Xinyuan" sort="Zhou, Xinyuan" uniqKey="Zhou X" first="Xinyuan" last="Zhou">Xinyuan Zhou</name>
<name sortKey="Zhou, Yuyang" sort="Zhou, Yuyang" uniqKey="Zhou Y" first="Yuyang" last="Zhou">Yuyang Zhou</name>
</country>
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The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection.

The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection.

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